关于心血管风险的弗雷明汉姆肥胖症指数的预测价值:一项基于全国人口的队列研究
Yun Kyung Cho1,2, Myungjin Kim1, Ye-Jee Kim3
1Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
弗雷明翰脂肪酸指数 (FSI) 是非酒精性脂肪肝疾病 (NAFLD) 的标志物,可以预测心血管事件风险. 较高的FSI得分表明主要不良心血管事件 (MACE) 和心血管事件的风险增加.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 流行病学 流行病学
背景情况:
- 非酒精性脂肪肝疾病 (NAFLD) 很普遍,与心血管疾病 (CV) 和死亡率有关.
- 弗雷明翰脂肪酸症指数 (FSI) 是NAFLD的拟议诊断标志物,使用临床和生化参数计算.
- 大规模的人口数据对于验证新型风险预测标志物至关重要.
研究的目的:
- 评估FSI对心血管风险的预测能力.
- 评估FSI与主要不良心血管事件 (MACE),心血管事件和心血管死亡率之间的关联.
- 为了验证FSI作为一个预后工具在一个大韩国人口队列.
主要方法:
- 利用了来自韩国国家健康保险服务-国家健康查队列 (NHIS-HEALS) 的数据.
- 包括283,427名参与者在排除死亡率,之前的CV事件和重度饮酒后.
- 使用Cox比例危险回归分析与调整和未调整的模型来评估FSI与CV结果的关联.
主要成果:
- 在5.9年的时间里,较高的FSI四分位数显示了MACE和心血管事件的显著,分级增加.
- 对MACE的调整危险比率与FSI四分位数逐渐增加.
- 在风险因素调整后,FSI和心血管死亡率之间的关联没有达到统计学意义.
结论:
- 作为NAFLD的替代标记物,FSI证明了用于识别心血管事件风险较高的个体的预后价值.
- 在患有NAFLD或面临NAFLD风险的人群中,FSI可以帮助早期检测和对心血管疾病的风险分层.
- 进一步的研究可能会探索提炼FSI或将其与其他标记物相结合,以进行全面的CV风险评估.
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