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相关概念视频

Proteomics01:33

Proteomics

7.4K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.4K

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相关实验视频

Updated: Jul 20, 2025

TMT Sample Preparation for Proteomics Facility Submission and Subsequent Data Analysis
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TMT Sample Preparation for Proteomics Facility Submission and Subsequent Data Analysis

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组织蛋白质组学存储库用于数据再分析.

Rafael Stroggilos1, Aggeliki Tserga1, Jerome Zoidakis1

  • 1Biomedical Research Foundation, Academy of Athens, Department of Biotechnology, Athens, Greece.

Mass spectrometry reviews
|August 3, 2023
PubMed
概括

蛋白质组学数据库正在增长,但一半的人体组织数据集缺乏必要的元数据,无法重复使用. 改善元数据提交对于推进系统生物学研究至关重要.

关键词:
骄傲是一种自豪感.蛋白质组X 变换X 变换数据存储库数据存储库.质谱测量质谱测量质谱测量质量测量质谱测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量蛋白质组学 蛋白质组学组织组织组织组织组织.

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Last Updated: Jul 20, 2025

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科学领域:

  • 蛋白质组学是指蛋白质组学.
  • 系统生物学 系统生物学
  • 生物信息学是一种生物信息学.

背景情况:

  • 蛋白质组学存储库已经存在了近二十年,积累了大量的质谱数据.
  • 该领域正在成熟,标准化术语和文件格式,将蛋白质组学整合到系统生物学中.
  • 蛋白质组Xchange是一个蛋白质组数据存储库的联盟.

研究的目的:

  • 从2015年到2022年,评估ProteomeXchange存储库中的公共人体组织数据集.
  • 将现有信息映射出来,并评估这些数据集的可重复使用性.
  • 确定改善蛋白质组学数据共享的挑战和机会.

主要方法:

  • 在ProteomeXchange.com中搜索,收集和评估公开的人体组织数据集,这些数据集被归类为"完整".
  • 根据疾病类别 (癌症,神经元,心血管) 分析的数据表示.
  • 评估了数据集注释和元数据的完整性,以便可复制.

主要成果:

  • 人体组织数据占提交总数的10-25%,癌症最多.
  • 大约50%的审查数据集缺乏足够的元数据来直接复制分析.
  • 在过去的七年里,蛋白质组学存储库在尺寸和功能方面显著增长.

结论:

  • 由于不完整的元数据,确保蛋白质组学数据的可重复使用仍然存在重大挑战.
  • 需要提高社区意识,并采用诸如"mage-tab"文件格式之类的元数据标准.
  • 确保所有提交的详细元数据是蛋白质组学存储库的下一个关键里程碑.