来自307例肝的单心队列中的15例病例的分析
Etienne Canouï1, Geoffrey Rossi1, Yann Nguyen1
1Department of Internal Medicine, Beaujon Hospital, GHU AP-HP. Nord-Université Paris Cité, Paris, France.
Mycoses
|August 3, 2023
概括
坎迪达炎性肝 (C-PLA) 是罕见但严重的,通常与并发症和败血症有关. C-PLA病例显示出更高的复发风险,这表明需要更密集的治疗策略.
科学领域:
- 医学真菌学 医学真菌学
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
背景情况:
- 在发热性肝 (PLA) 中很少发现Candida物种,特别是在血液病患者环境之外.
- 这项研究重点关注Candida发热性肝 (C-PLA),将其与细菌性PLA (B-PLA) 区分开来.
研究的目的:
- 调查C-PLA.的风险因素,临床和微生物特征,管理和结果.
- 将C-PLA病例与B-PLA病例进行比较,以确定不同的特征和关联.
主要方法:
- 从单心肝瘤数据库 (2010-2018) 中对C-PLA和B-PLA病例进行了回顾性分析.
- 不良疗程的定义包括治疗失败,复发或在3个月内死亡.
- 采用多变量分析来确定独立的风险因素和关联.
主要成果:
- 分析了15例C-PLA和292例B-PLA病例;所有C-PLA病例都是出于胆汁和多微生物.
- 患有C-PLA的患者经常有并发症,需要密集护理的败血症 (53.3%),以及42天的中位抗真菌治疗持续时间.
- 对C-PLA的独立风险因素包括恶性瘤史,以前的肝,以及严重程度标准的败血症. C-PLA与明显更高的复发风险有关.
结论:
- 在非中性衰竭患者中的Candida肝 represent一个罕见但严重的临床实体.
- 在C-PLA中观察到的高复发率需要考虑更积极和密集的治疗方案.
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