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17p的小克隆) 提供了复发性多发性骨髓瘤复发的储

Jian Cui¹, Rui Lv¹, Tengteng Yu²

¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin 300020, China; Tianjin Institutes of Health Science, Tianjin 301600.

|August 3, 2023

概括

多发性骨髓瘤 (MM) 中17p染色体的删除表明预后不佳,特别是当它在复发时作为小克隆出现时. 监测克隆进化是生存结果的关键.

科学领域:

血液学血液学血液学
在瘤学瘤学.
细胞遗传学细胞遗传学

背景情况:

染色体17p (del(17p)) 的删除是多发性骨髓瘤 (MM) 的显著预后因素.
在复发期间不同克隆大小的del ((17p) 的预后影响及其诊断后的演变仍然不清楚.

研究的目的:

为了研究在复发时del(17p) 克隆大小的预后价值.
分析del ((17p) 的克隆进化模式,从诊断到MM患者的复发.

主要方法:

对995名新诊断MM (NDMM) 和293名复发MM患者的相间光在位杂交 (iFISH) 数据的分析.
从诊断时和第一次复发时的197名患者的配对iFISH数据被用于跟踪克隆进化.

主要成果:

在复发时,而不是在诊断时,del ((17p) 的小克隆与MM存活率较差 (HR 1.64) 有关.
在疾病过程中获得del ((17p) 显著降低了整体存活率 (61.3 vs 49.4个月).
在56例复发患者中出现了新的细胞遗传异常,主要是del(17p).

结论:

在复发时存在较小的del 17p) 克隆,会对MM的预后产生不利影响.
了解克隆进化对于开发针对MM高风险细胞遗传异常的向疗法至关重要.

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