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在门诊临床试验中,与COVID-19康复期血相关的输血反应

Moises A Huaman¹, Jay S Raval², James H Paxton³

¹Department of Internal Medicine, Division of Infectious Diseases, University of Cincinnati, Cincinnati, Ohio, USA.

|August 3, 2023

概括

COVID-19康复性血 (CCP) 输血对高风险门诊患者来说是安全的. 与对照血相比,研究没有发现CCP增加过敏反应或不良事件的风险.

科学领域:

免疫学免疫学免疫学
传染性疾病传染性疾病
血液学血液学血液学

背景情况:

COVID-19康复性血 (CCP) 是高风险门诊患者的潜在治疗方法. 临床试验中的安全数据对于其治疗应用至关重要.
在门诊环境中评估输血反应对于了解CPT的现实安全概况至关重要.

研究的目的:

评估门诊COVID-19康复性血 (CCP) 输血的安全性.
为了确定CPC是否与高风险的COVID-19住院的门诊患者输血反应的风险增加有关.

主要方法:

来自美国两项随机对照试验的输血相关不良事件的分析.
使用多变量逻辑回归对比CPC与控制等离子体组.
针对潜在的混因素进行调整,包括先前存在的喘.

主要成果:

总体而言,5.9%的参与者出现了不良事件,主要是轻微的过敏反应 (尿疹/).
在CCP和控制等离子体组之间,过敏输血反应没有显著差异 (AOR 0.75).
在喘患者中观察到疹/的风险增加 (AOR 2.33);没有发现抗体介导疾病增强或感染风险增加.

结论:

门诊CPT管理是安全的,近1400名参与者安全地接受输血.
对于因COVID-19而面临住院危险的门诊患者来说,CPT是一种安全的治疗选择.
轻度过敏反应是最常见的不良事件,在CCP和对照组之间没有显著差异.

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