对脊椎动物神经发育的顶点定向细胞粘附的逐步调节
1Department of Psychology, Dalian Medical University, 9 South LvShun Road, Dalian, 116044, China.
Biological reviews of the Cambridge Philosophical Society
|August 3, 2023
概括
定向细胞粘附 (OCAs) 在神经发育过程中引导细胞重组. 反平行OCAs对于跨物种的神经管融合的保护至关重要,为组织管生成提供了洞察力.
科学领域:
- 发展生物学 发展生物学
- 细胞生物学 细胞生物学
- 生物物理学的生物物理.
背景情况:
- 神经发育是一个基本的发育过程,它将神经外皮转化为神经管.
- 这一过程涉及复杂的细胞重组,由细胞极性和粘附的变化驱动.
- 定向细胞粘附 (OCAs) 是这些细胞间关系的关键调节者.
研究的目的:
- 利用斑马鱼作为模型,探索OCAs在神经板逐步转化为神经管中的作用.
- 阐明OCAs介导的平行,反平行和对立的细胞间关系是如何促进神经发育的.
- 讨论OCAs的潜在调节剂,并比较物种间的神经细胞机制.
主要方法:
- 利用斑马鱼 (Danio rerio) 作为研究神经分泌的模型生物.
- 在神经管形成过程中分析了细胞极性和OCAs之间的配置关系.
- 在不同物种中参与神经发育的OCAs进行比较.
主要成果:
- 证明OCAs在神经板-基尔-棒-管转换过程中调节并行,反并行和对立的细胞间关系.
- 确定了反平行OCAs作为神经管融合所必不可少的保存机制.
- 讨论了粘附分子如卡德林,埃弗/埃弗林,克劳丁,奥克卢丁,碎片,Na+/K+-ATPase和整体在调节OCA中的参与.
结论:
- 在神经发育过程中,OCAs在编排细胞行为中起着至关重要的作用.
- 反平行OCAs代表神经管闭合的保存机制,对脊椎动物发育至关重要.
- 对OCAs的进一步研究将有助于更好地理解各种组织中的管体生成.
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