精神分裂症患者服用抗精神病药物的QTc延长:患病率和危险因素
Wei Du1, Meng-Wei Ge1, Fei-Hong Hu1
1School of Medicine, Nantong University, Nantong, Jiangsu, PR China.
Journal of psychopharmacology (Oxford, England)
|August 3, 2023
概括
这次元分析发现,服用抗精神病药物的精神分裂症患者中约有4.0%的患者经历了QTc延长. 女性和老年人面临更高的风险,需要警的心脏监测.
科学领域:
- 心脏病学 心脏病学
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- QTc延长是精神分裂症患者抗精神病药物使用的潜在并发症,增加恶性心律不整的风险.
- 之前的分析没有全面评估该人群中QTc延长的患病率和风险因素.
研究的目的:
- 进行一项元分析,评估在接受抗精神病药物治疗的精神分裂症患者中QTc延长的患病率.
- 为了确定与QTc延长相关的相关风险因素,在这个患者群体.
主要方法:
- 在Web of Science和PubMed进行了系统的文献搜索.
- 包括15540名患者的15项研究,研究质量使用纽卡斯尔-太华尺度 (NOS) 进行评估.
- 使用元分析和元回归来分析患病率和风险因素.
主要成果:
- 整体QTc延长的患病率为4.0% (95% CI:3.0%-5.0%).
- 流行率因地区而异:亚洲为4.0%,欧洲为5.0%,美洲为2.0%.
- 超回归表明,女性性别和年龄较大与患病率增加有关. 吸烟,心血管疾病和异常的脂质样本是潜在的导致因素.
结论:
- 大约4.0%的接受抗精神病药物的精神分裂症患者经历了QTc延长.
- 女性和老年患者是高风险群体,需要密切监测心电图.
- 识别和管理风险因素对于预防心脏并发症至关重要.
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