赫斯佩里丁通过激活SIRT1 - 分子对接,分子动力学模拟和实验验证来缓解急性瘤性胰腺炎
Rui Zhang1, Junjie Lan1, Qi Chen1
1Department of Pharmacy, Guizhou Provincial People's Hospital, 550002 Guiyang, China.
Combinatorial chemistry & high throughput screening
|August 3, 2023
概括
赫斯佩里丁通过激活SIRT1,减少炎症和亡,有效地治疗急性死性胰腺炎. 这种天然化合物显示出作为这种严重的胰腺疾病的治疗剂的希望.
科学领域:
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
- 细胞生物学 细胞生物学
背景情况:
- 急性瘤性胰腺炎是一种严重的胰腺损伤,治疗选择有限.
- 研究急性瘤性胰腺炎的新疗法至关重要.
研究的目的:
- 为了研究hesperidin对L-氨酸诱导的急性胰腺炎的治疗作用.
- 在急性胰腺炎中识别hesperidin的潜在分子标.
主要方法:
- 在小鼠中使用L-氨酸-HCl.Cl诱导了急性胰腺炎.
- 评估了hesperidin对胰腺和肺组织,血氨酶和髓氧化酶的影响.
- 使用in silico分子对接和模拟来研究hesperidin-protein相互作用.
主要成果:
- 赫斯佩里丁可以降低胰腺炎的严重程度,包括血氨酶,炎症,胀和亡.
- 赫斯佩里丁可以保护肺部免受损伤,并预防无细胞死亡和线粒体功能障碍.
- 赫斯佩里丁与SIRT1具有很高的结合亲和力,增加了其蛋白质水平;SIRT1的抑制取消了赫斯佩里丁的保护作用.
结论:
- 赫斯佩里丁通过激活SIRT1.1来缓解急性死性胰腺炎.
- 这项研究为治疗急性胰腺炎的天然化合物提供了洞察力.
- 赫斯佩里丁显示出作为急性死性胰腺炎的治疗剂的潜力.
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