在甲状腺功能低下症中,GlycA作为全身炎症的新型生物标志物
Sarah Galvao1, Isabela M Bensenor2, Michael J Blaha3
1Post-Graduate Program in Endocrinology, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
概括
炎症和心血管风险的标志物糖蛋白乙 (GlycA) 水平在治疗不充分的甲状腺功能低下症患者中升高. 最佳的Levothyroxine (LT4) 治疗与较低的GlycA水平有关,这表明心血管风险概况有所改善.
科学领域:
- 内分泌学 在内分泌学.
- 心血管医学 心血管医学
- 生物标志物 生物标志物
背景情况:
- 糖蛋白乙 (GlycA) 是一种用于系统性炎症和心血管风险的新生物标志物.
- 甲状腺功能低下症是一种甲状腺激素不足的情况,会影响许多身体功能.
- 了解甲状腺功能低下症中的GlycA水平对于评估相关心血管风险至关重要.
研究的目的:
- 评估甲状腺功能低下症患者的GlycA水平.
- 为了研究用levothyroxine (LT4) 治疗的患者的GlycA水平,考虑到thyrotropin (TSH) 水平.
- 探索甲状腺状况,LT4治疗充足度和GlycA水平之间的关系.
主要方法:
- 对ELSA-巴西队列研究 (n=4745) 与血清TSH和GlycA测量的横截面分析.
- 优甲状腺 (EU),未诊断的低甲状腺症 (UH) 和LT4治疗患者的分类 (充分治疗[AT],不充分治疗[IT],包括过度治疗[OT]和治疗不足[UT]).
- 使用克鲁斯卡尔-瓦利斯,奇方位测试,恩的后 hoc 测试和多变量回归模型进行统计比较.
主要成果:
- UH的患病率为9.8%;只有61.7%的LT4治疗患者是AT.
- 治疗不充分的 (IT) 个体的GlycA水平高于无甲状腺患者 (429比410μmol/L,p<0.01).
- 在TPO-Ab+亚组中,IT和UH组的GlycA比euthyroid高.
- 与OT (432μmol/L) 和UT (423μmol/L) 患者相比,AT (405μmol/L) 患者的GLYCA水平较低.
结论:
- 不适当治疗的甲状腺功能低下症 (IT),包括治疗过度和治疗不足,与高GlycA水平有关.
- 在IT中高GlycA可能表明低度的全身炎症和潜在的心血管风险增加.
- 适当的勒沃甲状腺素 (LT4) 治疗与较低的GlycA水平有关,这表明对心血管健康的潜在益处.
相关概念视频
Synthesis and Regulation of Thyroid Hormones
4.7K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.7K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
119
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
119
Hypoglycemia and Glucagon
301
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
301
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
13
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
13
Hormones Regulating Blood Glucose
3.5K
Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...
In addition to accelerating glucose uptake and utilization, insulin has...
3.5K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
355
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
355


