在静脉弹性Pycnogenol®-Centellicum®的积极影响:一个ex-vivo概念研究研究
Gianni Belcaro1, Mark Dugall2,3,4, Morio Hosoi2,3,4
1Irvine3 Circulation Sciences, G. D'Annunzio University, Pescara, Italy - cardres@abol.it.
在ex-vivo测试中,Pycnogenol®-Centellicum®补充剂改善了静脉弹性. 这种口服补充剂增强了静脉段在压力后恢复形状和大小的能力,这表明在管理静脉健康方面可能发挥作用.
科学领域:
- 血管生物学 血管生物学
- 药理学 药理学是指药理学的学科.
- 生物医学工程 生物医学工程
背景情况:
- 研究Pycnogenol®-Centellicum®口服补充剂对静脉弹性的疗效.
- 使用了来自移植和手术的活体静脉段.
研究的目的:
- 评估Pycnogenol®-Centellicum®对静脉弹性和动态应力后恢复的影响.
- 评估补充剂在改善静脉壁色调方面的潜力.
主要方法:
- 从59个受试者的静脉段 (正常和静脉静脉) 进行了ex-vivo测试.
- 静脉段经受扩大,延长和扭力应力测试.
- 对照组与在手术前4周补充Pycnogenol®-Centellicum®的组之间的比较.
主要成果:
- 补充正常静脉段显示在扩大,延长和扭曲测试后显著改善恢复 (P<0.05).
- 来自补充剂的受试者的静脉细分显示了较高的恢复率 (51.7%) 与对照组 (16.6%) 相比 (P<0.05).
- 皮克诺日 (Pycnogenol®-Centellicum®) 增强了静脉片段在应激后恢复原始尺寸的能力.
结论:
- 补充Pycnogenol®-Centellicum®显著改善了正常静脉和静脉静脉的静脉弹性.
- 该补充剂可能有助于缓解被动静脉扩张,可能减缓静脉的进展.
- 改善静脉弹性和更快的恢复表明对静脉壁色调有保护作用.
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