前向和反向排型差异和ABO血型的交叉匹配不相容:原因分析和治疗
Hongmei Qiu1, Xuechun Wang1, Yan Shao2
1Department of Blood Transfusion, The First Hospital of Jiaxing, Jiaxing, People's Republic of China.
Hematology (Amsterdam, Netherlands)
|August 3, 2023
概括
在 ABO 血型和交叉匹配中存在差异是由于各种因素造成的,例如类型减弱或抗体. 仔细的查和抗原匹配输血对于安全的临床输血实践至关重要.
科学领域:
- 输血医学 输血医学
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
背景情况:
- 准确的 ABO 血型分类和交叉匹配对于安全的输血至关重要.
- 前进和反向输入之间的差异可能导致输血错误.
研究的目的:
- 分析 ABO 血型分类 (前向和反向) 中不匹配的原因.
- 调查交叉匹配不兼容性的原因.
主要方法:
- 使用生理盐水,聚胺和抗人类球蛋白方法来识别类型差异的抗体.
- 用于对阳性样本进行抗体查以进行详细的鉴定.
主要成果:
- 导致前向/反向类型差异的因素包括血清类型的减弱,rouleaux形成,单克隆免疫球蛋白效应,骨髓移植和血型亚型.
- 交叉匹配不兼容的原因被确定为同源抗体,温暖自身抗体,冷自身抗体和达拉图马布.
结论:
- 定期的红细胞抗体查,考虑到患者病史,是必不可少的.
- 选择抗原匹配的红细胞和采用多种测试方法可确保临床输血安全.
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