儿科脏移植接受者的脂质异常 在类固醇戒断维护免疫抑制 儿科脏移植接受者
Emily Zangla1, Ruchi Mahajan2, Ziou Jiang3
1Department of Pediatrics, Division of Nephrology, University of Minnesota, Academic Office Building, 2450 Riverside Ave S AO-201, Minneapolis, MN, 55454, USA. zangl015@umn.edu.
Pediatric nephrology (Berlin, Germany)
|August 3, 2023
概括
脂质异常常见于类固醇戒断的儿科脏移植接受者 (pKTR),超过64%受影响. 很少有患者接受专家推或他类药物治疗,这表明护理的差距.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 儿科内分泌学 儿科内分泌学
- 预防心血管疾病 预防心血管疾病
背景情况:
- 脱脂症是心血管疾病的一个显著的,可修改的危险因素.
- 在现代免疫抑制的儿科移植接受者 (pKTR) 中脱脂症的患病率和特征尚未得到充分确立.
- 这项研究调查了接受类固醇戒断免疫抑制的pKTR中的脂质异常.
研究的目的:
- 为了确定在类固醇戒断时pKTR中脱脂症的患病率.
- 为了确定与这种人群中脂质异常相关的风险因素,并发病症和治疗模式.
- 评估脂质水平与临床参数 (如BMI和eGFR) 之间的相关性.
主要方法:
- 脂质查在96 pKTR (年龄≤21岁) 进行,这些人接受了类固醇戒断免疫抑制治疗.
- 统计分析包括威尔科克森的等级和,奇平方/费舍尔的精确测试,皮尔森的总胆固醇和BMI的相关性,以及预测因子的多变量逻辑回归.
- 数据是在2020年1月1日至2022年9月30日期间收集的.
主要成果:
- 在64.6%的pKTR中观察到高频率的禁食脂质异常.
- 总胆固醇与BMI有显著的正线性相关性 (r=0.38,p=0.0022).
- 较高的eGFR与较低的脂质异常几率相关 (OR 0.979,p=0.026),胰岛素治疗糖尿病在异常患者中更为普遍 (12.9%与0%,p=0.047).
结论:
- 脂质异常在pKTR中非常普遍,但治疗干预并不频繁.
- 使用卡尔西纽林抑制剂进行类固醇戒断免疫抑制可能无法预防脂质不良症.
- 估计较高的淋巴膜过率 (eGFR) 与pKTR. lipid异常的流行率降低有关.
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