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Updated: Jul 20, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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小分子疏水标记:一种类似药物技术的有希望的策略,用于向蛋白质降解

Shaowen Xie1, Jingjie Zhu1, Junda Li1

  • 1Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiangsu 211198, China.

Journal of medicinal chemistry
|August 3, 2023
PubMed
概括

疏水标签 (HyTs) 为药物发现提供了有希望的向蛋白质降解 (TPD) 的新前沿. 这些分子增强了类似药物的特性,使得以前难以捉摸的蛋白质成为目标.

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Eukaryotic cells can degrade proteins through several pathways. One of the most important amongst these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
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