相关实验视频

Updated: Jul 20, 2025

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis
08:55

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis

Published on: August 7, 2018

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准MLKL的PROTACs保护细胞免受死细胞灭绝

Oliver H Rathje1,2,3, Lara Perryman1, Richard J Payne2,3

  • 1Pharmaxis Ltd., 20 Rodborough Road, Frenchs Forest, NSW 2086, Australia.

Journal of medicinal chemistry
|August 3, 2023
PubMed
概括

研究人员开发了新的PROteolysis TTargeting Chimeras (PROTACs) 来降解混合血统激酶域类伪激酶 (MLKL). 这种方法有效地抑制了亡,为MLKL相关疾病提供了新的治疗策略.

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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs10:44

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

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