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发现AD258作为具有强烈抗代活性的西格玛受体连接体

Maria Dichiara1, Francesca Alessandra Ambrosio2, Sang Min Lee3

  • 1Dipartimento di Scienze del Farmaco e della Salute, Università degli Studi di Catania, Viale Andrea Doria 6, 95125 Catania, Italy.

Journal of medicinal chemistry
|August 3, 2023
PubMed
概括

研究人员开发了新的西格玛受体 (SR) 连接体来缓解疼痛. 化合物9d (AD258) 在没有运动障碍的临床前模型中显示出高亲和力,低毒性和强大的止痛作用.

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