在怀孕前或怀孕期间接种季节性流感疫苗时,流产的风险
Annette K Regan1, Amelia K Wesselink, Tanran R Wang
1School of Nursing and Health Professions, University of San Francisco, Orange, and Fielding School of Public Health, University of California, Los Angeles, Los Angeles, California; Boston University School of Public Health, Boston, Massachusetts; and Brown University School of Public Health, Providence, Rhode Island.
在怀孕前或怀孕期间接种季节性流感疫苗并没有增加流产风险. 这项研究分析了6,946次怀孕的数据,发现接种疫苗和未接种疫苗的个体中流产率相似.
科学领域:
- 生殖健康 生殖健康
- 疫苗学 疫苗学 疫苗学
- 流行病学 流行病学
背景情况:
- 建议孕妇接种季节性流感疫苗.
- 怀孕期间接种疫苗的安全性存在担忧,特别是流产的风险.
- 前性队列研究对于评估孕妇群体疫苗安全性至关重要.
研究的目的:
- 评估季节性流感疫苗接种与流产风险之间的关联.
- 评估疫苗接种时间 (怀孕前或早期) 对流产风险的影响.
- 使用倾向分数方法调查潜在的混因素.
主要方法:
- 从前性在线怀孕研究 (PRESTO) 队列 (2013-2022) 的数据分析.
- 包括6,946例怀孕与自我报告的疫苗接种和流产数据.
- 使用考克斯的比例危险模型,具有时间变化的暴露和倾向性得分分层,以控制混因子.
主要成果:
- 23.3%的女性参与者报告在怀孕前或怀孕初期接种了流感疫苗.
- 流感疫苗接种与流产率的增加无关 (怀孕前HR 0.99,怀孕期间HR 0.83).
- 男人伴侣接种疫苗也没有增加流产风险 (HR 1.17).
结论:
- 季节性流感疫苗接种在怀孕前或怀孕初期没有增加流产风险.
- 这些发现支持孕妇接种流感疫苗的安全性.
- 进一步的研究可以探索不同人群中的疫苗安全性.
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