多环芳 (PAH) 对怀孕,胎盘和胎盘 trofhoblasts 的影响
Yifeng Dai1, Xijin Xu2, Xia Huo3
1Division of Medical Biology, Department of Pathology and Medical Biology, University Medical Center Groningen and University of Groningen, Hanzeplein 1, 9713 GZ Groningen, the Netherlands; Laboratory of Environmental Medicine and Developmental Toxicology, Shantou University Medical College, 22 Xinling Rd, Shantou 515041, Guangdong, China.
怀孕期间暴露于多环芳 (PAH) 可能会损害胎盘发育和胎儿的结果. 研究表明,PAHs会影响热囊细胞,可能导致不良的妊娠和分娩结果.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 生殖生物学 生殖生物学
背景情况:
- 多环芳 (PAH) 是持久性有机污染物,具有已知的致癌和有毒作用.
- 在母体和胎儿血液和胎盘中检测到PAHs,引发了对发育影响的担忧.
- 胎盘暴露于PAH可能会影响怀孕和胎儿发育.
研究的目的:
- 审查有关PAH及其代谢物对妊娠结果影响的当前知识.
- 要总结PAHs对胎盘 trofhoblast 细胞的影响.
- 突出需要进一步研究PAH在胎盘发育中的毒性.
主要方法:
- 对人类胎盘中PAH-DNA添加物和高优先级PAH的流行病学研究的审查.
- 对检查PAH和代谢物对热囊细胞功能影响的体外研究的分析.
- 检查研究PAH对胎盘细胞和怀孕的影响的动物研究.
主要成果:
- 流行病学研究将胎盘PAH暴露与胎儿不良结果联系起来.
- 实验室研究表明,PAH混合物和甲烯 (BaP) 代谢产物会影响 trofhoblast 的活力,分化,迁移和入侵.
- 动物模型表明BaP代谢物对热囊细胞的影响,以及与流产的相关性.
结论:
- 和它们的代谢物可能会对胎盘 trofhoblast 细胞产生负面影响.
- 胎盘PAH暴露与不良的怀孕和分娩结果有关.
- 需要进一步的研究来阐明PAH对胎盘 trofhoblasts 和怀孕的具体影响.
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