自SARS-CoV2大流行以来,儿童重症监护病人的鼻病毒患病率不断增加
Eliza Gil1, Sunando Roy2, Tim Best3
1Department of Clinical Research, London School of Hygiene and Tropical Medicine; Department of Microbiology, Virology & Infection Control, Great Ormond Street Hospital for Children, UK; Infection, Immunity and Inflammation Department, GOS Institute of Child Health, University College London, London, UK.
儿童重症监护室 (PICU) 的犀牛病毒 (HRV) 发病率在封锁期间下降,但随后升至前所未有的水平. 易受伤害的儿童中HRV感染的增加需要注意临床和感染控制策略.
科学领域:
- 儿童传染病 儿童传染病
- 病毒学 病毒学
- 流行病学 流行病学
背景情况:
- 犀牛病毒 (HRV) 是儿童常见的季节性病原体.
- COVID-19 流行病和相关的公共卫生措施显著改变了病毒流行病学.
- 在最初的封锁期间,HRV几乎从大奥蒙德街医院 (GOSH) 的儿科重症监护室 (PICU) 消失了.
研究的目的:
- 在GOSH的PICU患者中,在SARS-CoV-2出现后,调查HRV感染模式的变化.
- 在封锁后的脆弱儿科人口中分析HRV的发病率和基因型.
主要方法:
- 对来自GOSH PICU患者 (2019-2023) 的10950个鼻吸血病毒PCR样本进行了回顾性分析.
- 包括3083个阳性呼吸道病毒样本,其中1530个为HRV阳性.
- 从2020年8月到2021年1月对66个HRV隔离物进行测序,并追溯收集电子健康记录数据.
主要成果:
- 在最初的减少之后,HRV发病率迅速增加,超过了大流行前的水平.
- 多个HRV基因型出现并以高发病率全年循环.
- HRV感染的激增发生在PICU患者身上,与其他呼吸道病毒不同.
结论:
- 在GOSH PICU患者中,HRV感染的发生率明显高于SARS-CoV-2出现后的流行.与大流行前相比.
- 在免疫功能低下的儿童中,这种增加的HRV负担具有关键的临床和感染控制影响.
- 人力资源价值增加的独特模式突出显示了一种独特的流行病学转变,影响了脆弱的儿科人口.
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