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Updated: Jul 20, 2025

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在结直肠癌中,PERK功能的丧失通过降低SLC7A11 (Xc−系统) 的下调促进铁亡

Krishan Kumar Saini1, Priyank Chaturvedi2, Abhipsa Sinha2

  • 1Division of Cancer Biology, CSIR-Central Drug Research Institute (CDRI), Lucknow, 226031, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh, 201002, India.

Redox biology
|August 3, 2023
PubMed
概括

展开的蛋白质响应 (UPR) 途径,特别是PERK,在耐治疗结直肠癌中调节铁化. 抑制PERK使癌细胞对铁亡敏感,提供了一个新的治疗策略.

关键词:
癌症 癌症 癌症 癌症压力ERER压力ERER压力铁化是铁化的一种.佩克 (Perk) 是一个名为"Perk"的东西.在 SLC7A1111 中.通过UPR进行全日制检查.

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