丸激素的使用会影响跨性别男性的H-MRS代谢物谱
Sarah Collet1, Sourav Bhaduri2, Meltem Kiyar3
1Department of Endocrinology, Ghent University Hospital, Ghent, Belgium.
Psychoneuroendocrinology
|August 3, 2023
概括
性别确认激素疗法 (GAHT) 影响跨性别男性的大脑代谢物,改变头顶皮层中的比例. 跨性别男性的杏仁体代谢物变化表明与性别障碍症发病相关的发展趋势.
科学领域:
- 神经成像是一种神经成像.
- 神经内分泌学神经内分泌学
- 代谢学 代谢学 代谢学
背景情况:
- 神经成像研究探讨了性别障碍症 (GD) 中的大脑内啡因型.
- 大脑的性别差异和性别肯定激素治疗 (GAHT) 对代谢物的影响还未得到充分研究.
研究的目的:
- 在经历了GAHT的跨性别男性中调查大脑代谢物变化.
- 在跨性别男性,半性别男性和半性别女性之间比较代谢物水平.
主要方法:
- 使用磁共振光谱 (1H-MRS) 对31名跨性别男性 (TM) 进行前后测试,与30名 cisgender男性 (CM) 和35名 cisgender女性 (CW) 相比.
- 评估了侧面顶膜皮层和杏仁体/前海马的代谢物度和比率.
- 测量的N-乙亚斯巴达酸盐 (NAA),肌酸 (Cr),胆 (Cho),谷氨酸/谷氨 (Glx),myo-inositol (mI) 和糖氨酸 (Gly).
主要成果:
- 在TM的侧顶皮层中,GAHT转移了myo-inositol (mI) + glycine (Gly) / creatine (Cr) 的比率.
- 在皮质皮层中,N-乙酸 (NAA) /Cr和胆 (Cho) /Cr的比率在 cisgender 女性 (CW) 和 cisgender 男性 (CM) 之间有所不同.
- 在TM中谷氨酸/谷氨胺 (Glx) 度和比率与桃体/前海马体中的CW不同.
- 在TM中GD发病的年龄调节的对Cr和NAA/Cr在杏仁体/前海马中产生影响.
结论:
- 通过GAHT给予丸激素会改变表皮层代谢物比率 (mI+Gly/Cr).
- 与GD发病相关的杏仁体代谢物变化表明潜在的发育影响.
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