库希综合征的长期后果:一个系统的文献综述
Soraya Puglisi1, Anna Maria Elena Perini1, Cristina Botto1
1Internal Medicine, San Luigi Hospital, Department of Clinical and Biological Sciences, University of Turin, 10043 Orbassano, Italy.
The Journal of clinical endocrinology and metabolism
|August 3, 2023
概括
即使在库希综合征 (CS) 缓解后,患者也经常经历持续的健康问题和增加的死亡率. 早期识别和持续管理并发症对于改善结果至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 内部医学 内部医学
- 临床研究 临床研究
背景情况:
- 内源性慢性皮质醇高分泌 (库希综合征,CS) 与显著的并发症有关.
- 这些包括心血管,代谢,肌肉骨,认知和情绪障碍,对生活质量和预期寿命产生负面影响.
研究的目的:
- 系统地审查当前证据,以了解库希综合征的缓解是否导致相关并发症的正常化.
- 评估CS缓解对患者发病率和死亡率的长期影响.
主要方法:
- 在Pubmed和Embase数据库上进行了系统的文献搜索.
- 包括2000年1月1日至2022年12月31日期间发表的研究.
- 79篇论文被选中,并根据共患病类型 (心脏代谢,血栓栓塞,骨,肌肉,情绪,认知,死亡率) 分类.
主要成果:
- 最近的证据表明,即使在长期缓解库辛综合征后,患病率和死亡率仍然持续增加.
- 伴随性疾病的正常化似乎取决于个体因素和特定疾病特征.
- 在许多研究中,患者数量有限,这阻碍了最终的结论.
结论:
- 库希综合征缓解并不总是保证相关并发症的完全正常化.
- 早期识别和全面管理CS,包括积极治疗并发病,是必不可少的.
- 建议对CS患者进行长期监测,即使是缓解后,也可用于管理持续的健康问题.
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