冠状病毒疾病后的中风2019年疫苗接种:基于现实世界研究不同设计的证据
Junyu Liu1,2, Fang Cao3, Chun Luo3
1Department of Neurosurgery, XiangYa Hospital, Central South University, Changsha, China.
The Journal of infectious diseases
|August 3, 2023
概括
根据一些研究设计,COVID-19疫苗接种可能与中风风险略微增加有关,特别是脑静脉鼻血栓症. 然而,接种疫苗的整体好处超过了这些潜在风险,建议不要犹接种疫苗.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 疫苗学 疫苗学 疫苗学
背景情况:
- 2019年冠状病毒病 (COVID-19) 疫苗接种和中风之间的关联需要彻底调查.
- 了解潜在的神经风险对于公共卫生政策和疫苗信心至关重要.
研究的目的:
- 系统评估COVID-19疫苗接种与中风风险之间的关联.
- 分析不同研究设计和子群体中缺血性中风 (IS),出血性中风 (HS) 和脑静脉鼻血栓症 (CVST) 的风险.
主要方法:
- 对队列,自我控制病例系列 (SCCS) 和案例交叉研究 (CCOS) 设计进行了系统的元分析.
- 针对COVID-19疫苗接种后的各种中风类型,计算了发病率风险比率 (IRR) 和95%置信区间 (CI).
- 亚组分析考虑了疫苗类型,剂量,年龄,性别和风险时期.
主要成果:
- 队列研究表明,接种疫苗后IS和HS的风险降低,但CVST的风险没有降低.
- 在接种疫苗后1-3周内,SCCS设计显示IS和HS的风险增加.
- 在ChAdOx1接种疫苗后,CCOS发现CVST的风险增加.
结论:
- 不同的研究设计在COVID-19疫苗接种后的中风风险方面产生了相互矛盾的结果.
- 尽管特定类型的中风可能增加,但COVID-19疫苗接种的好处被认为超过了风险.
- 这些发现表明,潜在的中风风险不应该阻止个人接种疫苗.
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