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Updated: Jul 20, 2025

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

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抑制性和激发性突触神经适应在耐受泽的脑中

Joshua M Lorenz-Guertin1, Nadya Povysheva2, Caitlyn A Chapman1

  • 1Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Neurobiology of disease
|August 3, 2023
PubMed
概括

二胺耐受性通过改变大脑信号来降低药物的有效性. 鼠标显示GABAergic抑制降低,Glutamatergic刺激增加,破坏治疗效果所需的平衡.

关键词:
二胺类药物的使用.在GABA(A) 受体上.这种NMDA受体是NMDA受体.蛋白质组学是指蛋白质组学.镇静 镇静 镇静 镇静宽容是一种宽容.

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