产前暴露于酸盐和幼儿的情绪/行为发展
Liron Cohen-Eliraz1, Asher Ornoy2, Eliana Ein-Mor3
1Psychology Department Hebrew University of Jerusalem, Jerusalem, Israel.
Neurotoxicology
|August 3, 2023
概括
产前暴露于Di-(2-乙烯基) 甲酸盐 (DEHP) 与24个月大的男孩的情绪和行为问题有关. 在母亲中,高DEHP暴露与较低的社会技能相关,并在男婴中增加了内化和外化问题.
科学领域:
- 环境健康 环境健康
- 发育儿科 发育儿科
- 毒理学 毒理学 毒理学
背景情况:
- 像酸盐这样的内分泌干扰化学物质 (EDC) 是无处不在的环境污染物.
- 孕前接触EDC被认为与不良的神经发育结果相关,包括儿童的行为困难.
研究的目的:
- 调查子宫内甲酸盐暴露与24个月龄的幼儿的情感和行为发展之间的联系.
主要方法:
- 在孕期早期 (11-18周) 采集了母亲的尿液样本,并对甲酸盐代谢物 (DEHP,DiNP,MBzBP) 进行了分析.
- 在24个月后,使用标准化母亲报告 (CBCL,ASQ-3,HOME问卷) 来评估后代的发育和行为.
- 多变量通用线性模型 (GLM) 用于分析甲酸盐代谢物水平和发育结果之间的关联.
主要成果:
- 孕产妇暴露于二甲基甲酸盐 (DEHP) 与男孩的行为和发育结果显著相关.
- 与暴露较低的男孩相比,高产前DEHP暴露的男孩在个人社会能力 (ASQ-3) 中的得分较低.
- 在男孩中,高DEHP暴露与增加的内化问题 (例如,情绪反应,焦虑,抑郁) 和外化问题有关.
结论:
- 怀孕早期母亲的DEHP代谢物度与24个月大的男孩的情绪和行为发育问题有关.
- 这些发现支持越来越多的证据证明DEHP是一种潜在的有害化学物质,需要对环境保持警.
- 这项研究强调了产前甲酸盐暴露对儿童发育的性别特异性影响.
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