相关实验视频

Updated: Jul 20, 2025

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects

Published on: May 4, 2021

对于NO气体治疗的L-氨酸自我递送的超分子纳米药物

Mengsi Zhang¹, Hao Jin¹, Yi Liu²

¹State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, PR China.

Acta biomaterialia

|August 3, 2023

概括

这项研究引入了一种新型的自传递纳米药物,用于氧化 (NO) 气体治疗瘤. 这种纳米药物有效地提供了l-arginine (L-Arg),并增强了瘤细胞的亡,同时防止过早的药物泄漏.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症治疗癌症治疗

背景情况:

氧化 (NO) 气体治疗为癌症治疗提供了一种具有扩大功效的微创方法.
对于像l-arginine (L-Arg) 这样的NO捐赠体的传统输送系统在循环过程中遭受过早泄漏.
开发基于NO的癌症治疗的稳定有效的输送系统仍然是一个重大挑战.

研究的目的:

开发一种高效的自我递送超分子纳米药物 (SDSND),用于瘤中增强的NO气体治疗.
为了克服与传统L-Arg输送系统相关的过早泄漏的局限性.
结合NO释放的治疗效益和L-Arg和EGCG对扩大瘤细胞亡的协同作用.

主要方法:

使用L-氨酸 (L-Arg), (-) -epigallocatechin gallate (EGCG) 和甲之间的曼尼赫反应合成的L-Arg自我递送的超分子纳米药物 (SDSND).
采用 π-π 堆叠来将 SDSND 自组装成纳米尺寸的粒子.
研究了由瘤微环境 (H2O2) 刺激的SDSNDs中NO的受控释放.

主要成果:

SDSNDs成功地输送了L-Arg,并在瘤微环境中释放了NO,诱导了亡.
曼尼赫反应和π-π堆叠策略可以防止L-Arg在血液循环过程中过早泄漏.
在SDSND中保留的功能组允许通过NO和EGCG的联合作用放大亡.
SDSNDs显示出高生物相容性和在瘤治疗中显著的治疗效果.

结论:

开发的L-Arg SDSNDs为NO气体治疗提供了有效和稳定的替代输送系统.
这种方法克服了药物过早泄漏的挑战,提高了治疗结果.
释放和EGCG协同作用的结合为放大瘤亡和治疗提供了一个有希望的策略.

关键词:

这是一种抗瘤药物.气体疗法是一种治疗方法.对于L-阿尔金宁来说,它是一种聚醇是一种多的化合物.超分子纳米药物超分子纳米药物

更多相关视频

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

相关概念视频

Drug Delivery: Enteral Route

Drug Delivery: Enteral Route

The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.

Nitric Oxide Signaling Pathway

Nitric Oxide Signaling Pathway

Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...

Drug Delivery: Miscellaneous Routes

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...