产前暴露于per-和多基基物质与儿童神经发育之间的关联:基于出生队列的证据
Xin-Xin Gao1, Qian-Lin Zuo1, Xi-Hang Fu1
1Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China; Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Environmental research
|August 3, 2023
概括
产前暴露在per-和多基基物质 (PFAS) 中与儿童神经发育不良有关,包括认知和行为不良. 对于其他神经学结果的确证据,需要更多的研究.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 发育儿科 发育儿科
背景情况:
- 有不一致的发现存在关于产前暴露在多基和多基物质 (PFAS) 和儿童神经发育.
- 了解各种PFAS类型对后代的影响至关重要.
研究的目的:
- 系统地审查和综合有关产前PFAS暴露和儿童神经发育的证据.
- 为了确定在怀孕期间受到PFAS暴露影响的特定神经发育结果.
主要方法:
- 在PubMed,Web of Science和EMBASE数据库中进行了全面的文献搜索,截至2023年3月.
- 仅包括报告产前PFAS暴露与儿童神经发育之间特定关联的出生队列研究.
主要成果:
- 31个出生队列研究被质量整合.
- 产前PFAS暴露与精神运动发育受损,外部化行为和整体发育有关.
- 对于其他神经学结果的证据有限,但注意到对社会行为和睡眠的性别特异性影响.
结论:
- 产前暴露于PFAS会对儿童神经发育的关键领域产生负面影响.
- 需要进一步的研究,以确定更广泛的神经结果的确证据.
- 性别特异性影响应在未来对PFAS和神经发育的研究中得到关注.
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