内生格雷林水平和饥饿感知:系统性审查和元分析
Kara C Anderson1, Faten Hasan1, Emily E Grammer1
1Department of Kinesiology, School of Education and Human Development, University of Virginia, Charlottesville, VA, United States.
Advances in nutrition (Bethesda, Md.)
|August 3, 2023
概括
格林,一种饥饿激素,与食欲感知有关. 乙烯酸格林 (AG) 显著加强了这种联系,这表明它在不同人群的饥饿信号中起着重要作用.
科学领域:
- 内分泌学 在内分泌学.
- 人体生理学 人体生理学
- 营养科学 营养科学
背景情况:
- 格林是一种氧化激素,有两种异型:乙化格林 (AG) 和去乙化格林 (DAG).
- 这些异构体可能在人类食欲调节方面具有不同的功能.
研究的目的:
- 在健康成年人中系统地审查和元分析血格林度 (总,AG和DAG) 与饥饿感知之间的关联.
- 为了确定影响 ghrelin-hunger 关系的调节者.
主要方法:
- 47项研究 (1799名参与者) 的系统综述和元分析.
- 纳入标准侧重于健康的成年人,血激素采样,验证的饥饿量表,并排除食欲修改干预措施.
- 评估的调节者包括年龄,BMI,体脂百分比,食成分,能量摄入量,性别和格林异型.
主要成果:
- 格林度与饥饿感知有适度的相关性 (r = 0.43,P < 0.001).
- 格雷林异型显著缓解了这种关联:AG (r = 0.60,P < 0.001),TG (r = 0.215,P = 0.01) 和DAG (r = 0.53,P = 0.695).
- 年龄,BMI,体脂百分比,能量摄入量和食中的碳水化合物含量也是重要的调节因素.
结论:
- 格林与人类的饥饿感知有关,其中酸格林 (AG) 扮演着可能更大的角色.
- 需要进一步的研究来阐明脱化 ghrelin (DAG) 在饥饿感觉中的特定作用.
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