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胚胎发生过程中的变暖会诱导鱼类中持久的转录基因特征

Daniel M Ripley¹, Terence Garner², Samantha A Hook³

¹Division of Cardiovascular Sciences, Faculty of Biology, Medicine, and Health, The University of Manchester, Manchester, UK.

The Science of the total environment

|August 3, 2023

概括

早期的热量暴露会改变鱼类的基因网络,使它们变得不那么有组织. 转录组组织的这种变化会影响鱼类对后来的温度变化做出反应.

科学领域:

发展生物学发展生物学
基因组学就是基因组学.
生态生态学生态生态学

背景情况:

胚胎暴露于高温可能会导致组织可塑性的长期变化.
尽管有这些可塑性变化,但很少发现差异表达的基因,这表明有替代的发育编程机制.
转录结构架构,特别是基因网络组织,是开发编程的一个潜在机制.

研究的目的:

调查发育变暖对转录基因网络组织在晚年生活中的持续影响.
为了确定转录组组织的变化是否会影响个体对未来温度挑战的反应能力.

主要方法:

使用网络建模方法来分析转录基因数据.
他们研究了四种不同的鱼类:Scyliorhinus canicula,Danio rerio,Dicentrarchus labrax和Gasterosteus aculeatus.
计算和分析了基因网络和个体基因.

主要成果:

发育性变暖始终增加了所有四种物种对对基因相互作用网络的,表明基因相互作用结构较差.
在斑马鱼中,在发育期变暖的动物中,较高的个体基因与在后期生活温度适应期间基因表达变化的概率增加有关.
基因和表达变化概率之间的这种关联在对照养的动物中不存在.

结论:

胚胎发生过程中的热环境显著改变了成年鱼的转录组组织.
增加的网络可能代表一个结构较差的转录态状态,对表型可塑性有影响.
塑性发育编程涉及基因网络组织的变化,影响未来对环境变化的适应性反应.

关键词:

气候变化气候变化气候变化发展性可塑性发展性可塑性超图形 (Hypergraph) 是一个超图形.长期影响长期影响网络模型网络模型在RNA-seqqq.鱼是什么意思鱼是什么意思

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