相关实验视频
Updated: Jul 20, 2025

07:50
Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
Published on: September 18, 2020
5.6K
代谢健康状态与胃肠道癌症风险之间的关联
Haozhe Cui1,2, Fei Tian3, Yongliang Chen1,4
1School of Medicine, Nankai University, Tianjin, China.
Cancer research and treatment
|August 3, 2023
概括
代谢健康的肥胖症 (MHO) 在中国成年人中增加了胃肠癌的风险. 保持健康的新陈代谢状态和体重对于预防肠道癌症至关重要.
科学领域:
- 在瘤学瘤学.
- 代谢健康 代谢健康
- 流行病学 流行病学
背景情况:
- 肥胖与各种疾病有关,但代谢健康状态对疾病风险的影响尚不清楚.
- 在中国人群中,代谢健康状况与胃肠癌风险之间的关联需要研究.
研究的目的:
- 调查代谢健康状况与患胃肠道癌的风险之间的联系.
- 分析身体质量指数 (BMI) 和腰围 (WC) 对这一关联的影响.
主要方法:
- 分析了来自Kailuan研究的114,995名参与者的队列.
- 参与者根据BMI/WC和代谢状态进行了分类.
- 考克斯比例危险回归模型评估了胃肠道癌发病率的风险,平均随访时间为13.76年.
主要成果:
- 根据BMI,代谢健康的肥胖 (MHO) 个体表现出显著增加肠道癌的风险 (HR,1.54;95% CI,1.11至2.13) .
- 在使用WC类别时,没有发现MHO状态和肠道癌症风险之间的显著关联.
- 无论体重如何,在代谢上不健康的个体也表现出胃肠道癌的风险增加.
结论:
- MHO表型与胃肠道癌的风险增加有关.
- 代谢不健康,无论体重如何,都会增加胃肠道癌症的风险.
- 临床医生应在消化道癌风险评估中考虑代谢状态,并就代谢健康和体重管理提供建议.
相关概念视频
Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
Assessment of the Gastrointestinal System II: Health Perception Pattern
141
Assessing the gastrointestinal (GI) system is a complex process that begins with collecting subjective data. This data, collected through patient interviews, provides crucial insights into the patient's health history, perception patterns, and lifestyle habits, all contributing significantly to GI health.
Health Perception Patterns
Health perception patterns offer valuable insights into a patient's lifestyle habits and how they may impact their GI health. These patterns include:
Health Perception Patterns
Health perception patterns offer valuable insights into a patient's lifestyle habits and how they may impact their GI health. These patterns include:
141
Serum Laboratory Studies, Stool Test, Breath Test
381
Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
381
Barrett Esophagus-I: Introduction
124
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
124
Assessment of the Gastrointestinal System I: Subjective Data
225
Assessing the gastrointestinal (GI) system is a complex process that begins with collecting subjective data. This data, collected through patient interviews, provides crucial insights into the patient's health history, perception patterns, and lifestyle habits, all contributing significantly to GI health.
Health History
The initial step in assessing the GI system is obtaining a comprehensive health history. This includes inquiring about the patient's history or presence of problems...
Health History
The initial step in assessing the GI system is obtaining a comprehensive health history. This includes inquiring about the patient's history or presence of problems...
225
Psychoneuroimmunology: Diabetes and Cancer
47
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
47

