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红细胞输血,贫血,养,以及死性肠球炎的风险
1Department of Pediatrics, Emory University and Children's Healthcare of Atlanta, 2015 Uppergate Drive Northeast, Atlanta, GA 30322, USA.
Clinics in perinatology
|August 3, 2023
概括
在早产婴儿中死性肠球炎 (NEC) 可能受到红细胞 (RBC) 输血的影响. 在输血期间保留食可能会降低NEC风险,但需要更多的研究.
科学领域:
- 新生儿科学 新生儿科学
- 儿科胃肠病学 儿科胃肠病学
- 血液学 血液学 血液学
背景情况:
- 死性肠球炎 (NEC) 是早产婴儿疾病和死亡的重要原因.
- 严重的贫血和红细胞 (RBC) 输血与婴儿的肠道炎症有关,但它们在NEC中的因果作用尚不清楚.
- 观察性研究表明,在红细胞输血期间保留食可能会降低NEC风险.
研究的目的:
- 审查当前关于红细胞输血和NEC期间食之间的关系的数据.
- 检查红细胞输血在NEC病变发生中的潜在作用.
- 为了突出正在进行的随机试验调查这一关联.
主要方法:
- 对临床前模型和观察性研究的文献综述.
- 分析与NEC相关的红细胞输血期间养实践的数据.
- 相关临床试验发现的总结.
主要成果:
- 临床前和观察数据表明,红细胞输血,肠道炎症和NEC之间存在联系.
- 有证据表明,在红细胞输血期间不提供肠道食可能有助于预防NEC.
- 随机试验数据目前有限,但正在出现.
结论:
- 红细胞输血在NEC的确切因果作用需要进一步调查.
- 在红细胞输血期间的养做法代表了NEC预防的潜在可修改因素.
- 正在进行的随机试验对于建立最终的临床建议至关重要.
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