生物年龄在接受皮肤冠状动脉干预的患者中的临床意义
Mandeep Singh1, Abdallah El Sabbagh1, Bradley R Lewis2
1Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
Mayo Clinic proceedings
|August 3, 2023
概括
使用健康缺陷和功能障碍计算的生物年龄显著改善了心脏手术后老年人死亡率的预测. 这种综合方法提供了比单独的时间年龄更好的生存估计.
科学领域:
- 老年学是一门学科.
- 心脏病学 心脏病学
- 生物统计学 生物统计学
背景情况:
- 在接受皮肤冠状动脉干预 (PCI) 的老年人中评估长期死亡风险至关重要.
- 年代年龄是该人口中死亡率的有限预测因素.
研究的目的:
- 评估由健康缺陷和功能障碍产生的生物年龄是否能提高PCI后老年人死亡率预测.
- 为了比较生物年龄模型与时间年龄的预测能力.
主要方法:
- 对535名接受PCI的患者 (≥55岁) 进行前性研究.
- 生物年龄模型包括心血管缺陷,非心血管缺陷和功能障碍 (主观和客观).
- 评估所有原因死亡率的中位数是2.05年的随访时间.
主要成果:
- 与时间学年龄相比,来自综合缺陷和损伤的生物年龄显著改善了死亡率预测 (C指数0.77比0.65,P<.001).
- 功能障碍本身也改善了预测 (C指数0.75与0.65,P<.001).
- 基于缺陷的生物年龄显示出改善预测的趋势 (C指数0.71比0.65,P=.08).
结论:
- 从缺陷和功能障碍中得出生物年龄,大大提高了PCI后老年人生存率的估计.
- 功能障碍,特别是主观功能障碍,为所有原因和非心脏病死亡率提供了重要的预后信息.
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