大动脉分支几何学对腹腔大动脉压力和峰值壁应力的影响:流体结构相互作用研究
Jiri Jagos1, David Schwarz2, Stanislav Polzer2
1Faculty of Mechanical Engineering, Brno University of Technology, Technická 2896/2, 616 69 Brno, Czech Republic.
Medical engineering & physics
|August 3, 2023
概括
大动脉 - 阴茎分叉几何学,特别是较低的面积比 (AR),显著增加血压和腹腔大动脉 (AA) 的峰值壁应力. 这表明,降低的AR,而不是大动脉-阴茎角,可能是腹腔大动脉动脉瘤 (AAA) 发展的关键风险因素.
科学领域:
- 生物医学工程 生物医学工程
- 心血管研究研究心血管研究
- 计算流体动力学的流体动力学.
背景情况:
- 腹腔大动脉瘤 (AAA) 风险与高血压等因素有关.
- 大动脉-阴茎分叉几何学可能会影响大动脉压力和壁应力,可能预测AAA.
- 了解这些几何影响对于AAA风险评估至关重要.
研究的目的:
- 为了研究大动脉-阴茎分叉几何学对大动脉压力和壁应力的影响.
- 确定特定的几何参数是否可以作为腹腔大动脉动脉瘤 (AAA) 的预测指标.
主要方法:
- 使用双向合流体结构相互作用模拟的参数分析.
- 将动脉壁建模为具有非牛顿流体行为的同位素高弹性单层.
- 利用现实的脉动性血流边界条件,并考虑各种理想化和患者特定的几何形状.
主要成果:
- 峰值壁应力 (PWS) 和缩血压 (SBP) 对大动脉 - 阴茎角不敏感.
- 面积比率 (AR) 减少50%导致PWS增加了高达18.4%,SBP增加了高达18.8%.
- 较低的AR显著影响AA压力和应力.
结论:
- 降低面积比 (AR),通常是由于腹腔狭窄或衰老,增加腹腔大动脉血压.
- 较低的AR,而不是大动脉-阴茎角,被确定为AAA发展的潜在风险因素.
- 大动脉 - 阴茎分支的几何因素在AAA病变发生过程中发挥着重要作用.
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