评估肝脏活检与差异化肝细胞病变
Sarah E Umetsu1, Sanjay Kakar1
1Department of Pathology, University of California San Francisco, 505 Parnassus Avenue, Box 0102, San Francisco, CA 94143, USA.
Surgical pathology clinics
|August 3, 2023
概括
从小小的活检中诊断肝病变是很困难的. 本综述涵盖了染色和分子测试,以区分肝细胞病变,如焦点结节性增生,肝细胞腺瘤和肝细胞癌 (HCC).
科学领域:
- 肝胆病理学 肝胆病理学
- 诊断病理学的诊断病理学
- 分子病理学分子病理学
背景情况:
- 肝病变的针芯活检带来了诊断挑战,特别是在有限的组织的情况下.
- 在肝硬化和非肝硬化肝脏中,区分分别的肝细胞病变需要仔细评估.
- 关键的差异包括焦点结节性增生,肝细胞腺瘤,失生性结节和明显分化的肝细胞癌 (HCC).
研究的目的:
- 审查诊断工具,以区分差异化肝细胞病变.
- 要突出体质化学和免疫体质化学染料的实用性.
- 讨论在肝细胞腺瘤诊断中的分子试验和临床病理场景.
主要方法:
- 对体内化学和免疫体内化学染色技术的审查.
- 对肝病变诊断相关的分子测定分析.
- 描述肝细胞腺瘤亚型的临床病理特征.
主要成果:
- 特定的斑点和分子标记物有助于区分具有挑战性的肝病变.
- 了解肝细胞腺瘤亚型的特征对于准确诊断至关重要.
- 分析了常见的临床病理情景,以获得诊断的清晰度.
结论:
- 组织化学,免疫组织化学和分子方法对于从有限的活检中诊断肝病变至关重要.
- 精确区分肝细胞病变可以改善患者的治疗.
- 本综述为在肝胆病理学中的差异诊断提供了一个框架.
相关概念视频
01:25Ultrasound II: Endoscopic Ultrasound and FibroScan
139
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Endoscopic Ultrasound (EUS):
139
01:27Liver Histology
891
The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
Hepatocytes perform a variety of essential functions. They secrete...
891