使用FDA不良事件报告系统数据库对sevoflurane诱导的神经发育性糖尿病无味症进行生物信息学引导的不成比例分析
Akhil T Jacob1, Ankitha Hari Kumar1, Gayethri Halivana1
1Department of Pharmacy Practice, Oxbridge College of Pharmacy, Bengaluru, India.
British journal of clinical pharmacology
|August 3, 2023
概括
塞沃弗兰的使用与神经性糖尿病无味症有关. 这项研究使用数据挖掘和分子对接来确定这种关联,强调需要临床谨慎和报告不良事件的必要性.
科学领域:
- 药物监督 药物监督 药物监督
- 麻醉学 麻醉学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 塞沃弗兰是一种广泛使用的吸入麻醉剂.
- 原性糖尿病无味症 (NDI) 是一种疾病,其特点是脏无法对抗尿激素做出反应.
- 塞沃和NDI之间的潜在联系需要进行调查.
研究的目的:
- 使用数据挖掘算法,检测sevoflurane和原性糖尿病无味症之间的潜在关联.
- 通过分子对接来研究由赛沃兰诱导的NDI背后的分子机制.
主要方法:
- 对2004-2022年FDA不良事件报告系统 (FAERS) 数据库的分析.
- 使用报告几率比率 (ROR) 和比例报告比率 (PRR) 的不成比例分析.
- 使用AutoDock Vina进行分子对接模拟,以评估与水素-2 (AQP2) 和血管压素V2受体 (AVPR2) 的结合亲和力.
主要成果:
- 在sevoflurane和NDI之间发现了一个统计学上显著的关联 (ROR=76.012,PRR=75.72).
- 报告的14例与塞沃兰有关的NDI病例中,50%需要住院治疗,14%是致命的.
- 分子对接显示了sevoflurane与AQP2 (-4.9 kcal/mol) 和AVPR2 (-5.3 kcal/mol) 的高结合亲和力.
结论:
- 黄素的使用显着与原性糖尿病发病率的增加有关. insipidus.
- 医疗保健专业人员应谨慎使用西沃兰,并报告不良事件.
- 需要进一步的研究来验证这些发现并确定风险因素.
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