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Updated: Jul 20, 2025

Visualizing the Conformational Dynamics of Membrane Receptors Using Single-Molecule FRET
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Published on: August 17, 2022

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诱导适应描述了对膜相关的细胞染色体P450 3A4的干结合

David Tyler Sweeney1, Francisco Zárate-Pérez1, Kamila Stokowa-Sołtys1

  • 1Department of Chemistry and Biochemistry and Biomolecular Sciences Institute, Florida International University, Miami, Florida (J.C.H., K.S.S., F.Z.P.); Department of Physiology and Biophysics and The Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia (D.T.S.); and Department of Biological and Medicinal Chemistry, Faculty of Chemistry, University of Wroclaw, Wroclaw, Poland (K.S.S.).

Molecular pharmacology
|August 3, 2023
PubMed
概括

使用抑制剂研究了细胞染色体P450 3A4 (CYP3A4) 酶结合机制. 结果表明诱导适应模型,而不是形状选择,更好地解释了CYP3A4如何适应各种药物分子.

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