什么是预测高度软组织肉瘤患者的生存率的有用标志物,这些患者有非炎症性疾病?
Tomoki Nakamura1, Kunihiro Asanuma1, Tomohito Hagi1
1Department of Orthopedic Surgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu City, Mie, 514-8507, Japan.
概括
对于具有良好修改格拉斯哥预后得分 (mGPS) 的高度软组织肉瘤患者,更高的绝对中性粒细胞计数 (ANC) 和更大的瘤大小表明预后更差,转移风险增加.
科学领域:
- 在瘤学瘤学.
- 肉瘤研究研究 肉瘤研究
- 生物标志物发现发现
背景情况:
- 修改格拉斯哥预后得分 (mGPS) 用于预测软组织肉瘤 (STS) 的结果.
- 高度STS和mGPS为0的患者仍然存在转移和死亡的风险.
- 这一特定患者群体的预后指标尚未明确.
研究的目的:
- 确定高度STS患者的生存和转移的预后指标,其mGPS为0.
- 评估绝对中性粒细胞计数 (ANC) 和瘤大小在这个队列中的作用.
主要方法:
- 包括104名高度STS和mGPS为0的患者 (CRP<1.0 mg/dl,白蛋白>3.5 g/dl).
- 使用Cox比例危险分析进行多变量分析.
- 平均随访期为79个月.
主要成果:
- 疾病特异性5年生存率 (DSS) 为79.2%.
- 瘤大小和绝对中性粒细胞数 (ANC) 是显著的预后变量.
- 较高的ANC (>3370/μl) 与更糟糕的DSS (74.7%对91.7%) 和转移风险增加 (59.5%对87.3%的无转移存活率) 相关.
结论:
- 绝对中性粒细胞计数 (ANC) 和瘤大小是高度STS患者的关键预后指标,mGPS为0.
- 升高的ANC和较大的瘤大小与更高的转移风险和较差的生存结果相关.
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