一种肠道脂赋予了代际的神经保护
Wenyue Wang1, Tessa Sherry1, Xinran Cheng2
1Development and Stem Cells Program, Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, Australia.
Nature cell biology
|August 3, 2023
概括
孕产妇摄入的乌尔索酸可以通过增强脂转移来改善子女跨代的神经系统健康. 这种饮食干预可以防止轴突脆弱,并通过特定的分子通路改善传输.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 发展生物学 发展生物学
背景情况:
- 母亲的饮食和环境显著影响后代的健康.
- 母亲饮食选择对神经系统的跨代影响仍然不太清楚.
- 脂类是生物活性分子,在细胞功能中起着关键作用.
研究的目的:
- 为了研究母体尿酸消费对Caenorhabditis elegans神经系统的代际影响.
- 为了阐明基底的分子机制,乌尔索酸的神经保护作用跨代.
主要方法:
- 用乌尔索酸养Caenorhabditis elegans. 这是一个非常好的方法.
- 评估子孙的轴突传输和脆弱性.
- 研究基-1-酸盐及其代谢途径的作用,包括RME-2受体和酸胺酶-1 (asah-1) 基因.
- 分析脂体代谢的空间调节.
主要成果:
- 母亲摄入的乌尔索酸改善了轴突运输,并减少了后代的成年期轴突脆弱性,证明了代际神经保护.
- 神经保护通过增加母体对基-1-酸盐 (S1P) 的供应来调解.
- 肠对卵细胞的S1P转移,依赖于RME-2受体,对于这种效果至关重要.
- S1P在肠道上调节asah-1基因转录,而不适当的神经元表达会导致轴突缺陷.
结论:
- 母亲饮食中的乌尔索酸通过调节脂代谢,在C. elegans中提供了代际神经保护.
- 脊柱脂质平衡及其空间调节对于神经系统的发育和跨代人的健康至关重要.
- 脂质代谢物可以充当代际信使,突出显示了在生殖过程中母亲饮食的重要性.
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