局部获得的耐药性是否是植物中因效应因子引发的抗病机制?
Pierre Jacob1,2, Junko Hige1,2, Jeffery L Dangl3,4
1Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Nature plants
|August 3, 2023
概括
植物核酸结合氨酸丰富的重复受体 (NLR) 激活对病原体的免疫力. 这项研究提出,NLR触发的免疫功能作为隔离机制,利用局部获得的耐药性 (LAR) 来防止病原体的传播.
科学领域:
- 植物免疫力 植物免疫力
- 分子植物病原体相互作用
- 植物防御机制 植物防御机制
背景情况:
- 植物核酸结合氨酸丰富的重复受体 (NLRs) 是细胞内免疫受体,检测病原体病毒效应因子.
- NLR激活启动了植物的免疫反应和抗病能力,但这些反应可以被效应器抑制.
- 免疫激活与受效体介导的抑制共存的机制尚不清楚.
研究的目的:
- 研究NLRs在植物对病原体免疫力的作用.
- 了解植物免疫反应在感染期间是如何空间调节的.
- 为效应器触发免疫 (ETI) 作为隔离机制提出一个模型.
主要方法:
- 在植物病原体相互作用中对效应因子触发免疫 (ETI) 的分析.
- 在感染部位周围观察防御基因表达模式.
- 对ETI与局部获得性耐药性 (LAR) 的比较.
主要成果:
- 在与Pseudomonas syringae pv.直接接触时,因效应器触发的免疫不能维持防御基因表达. 番茄 番茄 番茄 番茄 番茄
- 在感染部位周围的局部区域观察到强烈的防御反应,类似于局部获得性耐药性 (LAR).
- LAR是一种强烈的防御反应,在病原体接触的细胞周围的~2mm半径内,可能会防止病原体的传播.
结论:
- 建议以效应器触发的免疫作为隔离机制来防止系统性病原体的传播.
- 局部获得的耐药性 (LAR) 是这种隔离策略的关键组成部分.
- 这种机制通过将病原体制到最初感染区域来限制疾病.
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