3D到4D结构:生物医学应用的探索
Kadambari Borse1, Pravin Shende2
1Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM'S NMIMS, V. L. Mehta Road, Vile Parle (W), Mumbai, India.
AAPS PharmSciTech
|August 3, 2023
概括
4D打印是3D打印的进步,它使用智能材料制造改变形状的制药产品. 这项技术提供了增强的制造,降低成本和改进的药物输送系统,以获得更好的患者结果.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 制药科学 制药科学
背景情况:
- 传统的3D打印使得制造药品,如药物,多重药,纳米悬浮和水凝等制药产品成为可能.
- 3D打印的局限性包括材料限制,制造尺寸限制和设计错误.
- 4D打印作为一种进步而出现,利用活性材料进行刺激响应的形状变化.
研究的目的:
- 审查4D打印与3D打印在制药制造中的优势.
- 突出4D打印在智能药物输送系统中的最近临床应用.
- 强调4D打印在局部药物作用和改善患者服药性方面的潜力.
主要方法:
- 关于3D和4D打印技术在制药应用中的最新文献的综述.
- 分析智能材料的进步,例如形状记忆聚合物和液晶弹性体.
- 检查临床案例研究和4D打印设备的新兴应用.
主要成果:
- 与3D打印相比,4D打印提供了优越的打印能力,制造效率,产品质量和成本效益.
- 加入活性物质可以在应对外部刺激时进行动态的形状变化.
- 成功的临床应用包括人工植入物,4D打印器官,,微针和药物输送系统.
结论:
- 4D打印在先进的制药制造中比3D打印具有显著的优势.
- 通过4D打印制造的智能药物输送系统承诺局部化作用,减少给药频率,并提高患者的遵守性.
- 进一步的研究对于充分探索4D打印技术的未来发展和临床适用性至关重要.
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