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来自黑色素瘤捐赠者的器官移植的结果:系统性审查
William Hao Syuen Ng1, David John Curchin2, Stella McGinn3
1Faculty of Medicine, University of Newcastle, Newcastle, NSW, Australia.
International journal of dermatology
|August 3, 2023
概括
通过器官移植传染黑色素瘤是一个严重的问题. 一项审查发现,近58%的来自黑色素瘤捐赠者的器官接受者患上了癌症,这突显了显著的风险.
科学领域:
- 在瘤学瘤学.
- 移植手术 移植手术
- 公共卫生 公共卫生
背景情况:
- 器官移植是一种拯救生命的手术.
- 移植受体免疫抑制会增加癌症的风险.
- 黑色素瘤从捐赠者传播到接受者是一个明显的担忧.
研究的目的:
- 为了确定黑色素瘤从有黑色素瘤的器官捐赠者传播到接受者的风险.
- 审查器官接受者的结果,其捐赠者有黑色素瘤病史.
主要方法:
- 对PubMed,MEDLINE,Embase和JBI EBP数据库进行系统的文献审查.
- 搜索了有关黑色素瘤,器官捐赠,移植和传播的文章.
- 包括报告来自黑色素瘤捐赠者的接受者结果的研究.
主要成果:
- 选出了13篇文章,其中4篇来自参考列表.
- 75名器官接受者从已知黑色素瘤的捐赠者那里获得器官.
- 75名接受者中有43人 (57.3%) 患上了黑色素瘤.
结论:
- 从捐赠者传播黑色素瘤的最终定量风险尚未确定.
- 临床医生应考虑从有病史的捐赠者传播黑色素瘤的风险.
- 众多病例表明临床医生和移植计划存在重大关切.
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