相关实验视频

Updated: Jul 20, 2025

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function

Published on: May 4, 2021

肥胖引起的胰岛素抵抗的生物标志物:专注于微RNAs

Yichen Cai^1,2, Pan Liu^1,2, Yumei Xu^1,2

¹Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, Sichuan, China.

Diabetology & metabolic syndrome

|August 3, 2023

概括

像microRNAs (miRNAs) 这样的生物标志物可以预测与肥胖相关的胰岛素抵抗 (IR). 识别miRNA网络可能会改善早期风险分层和代谢障碍的治疗策略.

科学领域:

代谢性疾病是一种代谢性疾病.
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
发现生物标志物的发现.

背景情况:

肥胖和代谢综合征在全球范围内正在增加.
胰岛素抵抗 (IR) 是一种常见的肥胖并发症,个体发生率可变.
表观遗传因素,包括microRNAs (miRNAs),可能会影响IR发育.

研究的目的:

确定候选生物标志物用于与肥胖相关的IR早期风险分层.
总结一下与肥胖和IR相关的miRNA表达的最新进展.
强调当前生物标志物研究需要改进的领域.

主要方法:

在外周循环和组织中对miRNA表达变化的审查.
对患者和动物患有与肥胖相关的IR (过去5年) 的研究分析.
候选miRNA生物标记物的鉴定.

主要成果:

几种候选miRNA显示出预测与肥胖相关的IR的潜力.
现有的研究往往侧重于单个生物标志物,缺乏网络分析.
在与肥胖相关的IR患者中,MiRNA表达特征可能有所不同.

结论:

早期检测生物标志物,潜在的miRNA面板,对于管理与肥胖相关的IR至关重要.
通过miRNAs进行表观遗传调节可以解释肥胖症的各种临床结果.
未来的研究应该专注于miRNA网络和新疗法新疗法代谢途径.

关键词:

生物标志物生物标志物胰岛素耐药性胰岛素耐药性是一种微RNAs是一种微RNA.肥胖问题肥胖问题

更多相关视频

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance

Published on: February 17, 2023

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

Published on: January 7, 2018

相关概念视频

Obesity

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...

Insulin: The Receptor and Signaling Pathways

Insulin: The Receptor and Signaling Pathways

Insulin action is mediated through a receptor tyrosine kinase, akin to the IGF-1 receptor. The number of receptors per cell varies significantly, from 40 on erythrocytes to 300,000 on adipocytes and hepatocytes. The insulin receptor consists of linked α/β subunit dimers, forming a heterotetramer glycoprotein with two extracellular α subunits and two β subunits spanning the membrane. The α subunits inhibit the inherent tyrosine kinase activity of the β subunits, but...