对皮肤癌中基因与阳光暴露相互作用的系统审查
Rasha Shraim1,2,3, Mohamed Ziad Farran1,2, George He1,2
1Department of Public Health and Primary Care, Institute of Population Health, Trinity College Dublin, Dublin, Ireland.
Molecular genetics & genomic medicine
|August 4, 2023
概括
基因与环境的相互作用会影响皮肤癌的风险. 暴露在阳光下与特定的基因相互作用,这表明基因构成会影响紫外线辐射如何影响皮肤癌的发展.
科学领域:
- 皮肤病学 皮肤病学
- 遗传学 是一个遗传学.
- 流行病学 流行病学
背景情况:
- 皮肤癌风险受到环境因素的影响,如紫外线辐射 (UVR),个人习惯和遗传.
- 基因与环境 (GxE) 相互作用对于了解皮肤癌病因至关重要.
- 本综述调查了GxE关于皮肤癌风险的研究,并报告了影响估计.
研究的目的:
- 对皮肤癌中基因与环境相互作用的现有研究进行审查.
- 确定特定的基因及其与皮肤癌发展中的环境因素的相互作用.
- 报告这些基因与环境相互作用的估计影响.
主要方法:
- 在Embase,Medline和Web of Science搜索了关于GxE和皮肤癌的初级研究.
- 包括基础细胞癌 (BCC),状细胞癌 (SCC) 和黑色素瘤的研究.
- 使用纽卡斯尔-太华尺度评估研究质量;不能进行元分析.
主要成果:
- 最终综合包括了15项研究,12项使用候选基因方法.
- 发现了GxE与阳光照射相互作用的证据,这些基因包括MC1R,CAT,NOS1 (黑色素瘤),HAL,IL23A (BCC) 和HAL,XRCC1 (SCC).
结论:
- 阳光暴露与参与色素,氧化应激和免疫抑制的基因相互作用.
- 过度的紫外线暴露可能会根据基因构成对氧化防御和修复系统产生不同的影响.
- 建议进行进一步的研究,包括全基因组关联研究,以阐明依赖紫外线的疾病途径.
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