在开发由转基因植物生产的可食用疫苗方面,最近的进展和挑战
Smita Singh1, Pranjal Kumar Singh1, Kapil Sachan2
1SRM Modinagar College of Pharmacy, SRM Institute of Science and Technology, Delhi NCR Campus, Modinagar, UP, India.
Current protein & peptide science
|August 4, 2023
概括
在香等植物中生产的可食用疫苗,提供了一种具有成本效益和方便的方式来预防疾病. 克服技术和监管挑战是它们在全球卫生倡议中广泛使用的关键.
科学领域:
- 生物技术是生物技术.
- 植物分子生物学 植物分子生物学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 可食用疫苗代表了一种新的免疫方法,利用转基因植物生产疫苗抗原.
- 这项技术比传统疫苗具有潜在的优势,包括降低成本和更容易管理.
研究的目的:
- 审查可食用疫苗技术的现状,包括生产方法,宿主植物和益处.
- 讨论食用和皮肤内疫苗开发的挑战和最近的进展.
主要方法:
- 将基因引入植物,以产生针对疫苗的特定蛋白质 (抗原).
- 免疫原生产系统,分子特性和免疫反应的分析.
主要成果:
- 可食用疫苗可以在香和大米等各种作物中生产,提供低单位成本和方便的储存.
- 这些疫苗显示出降低乙型肝炎和霍乱等疾病患病率的潜力.
结论:
- 可食用疫苗是传统免疫接种的一种有希望的,具有成本效益的替代方案,具有预防疾病的巨大潜力,特别是在发展中国家.
- 技术和监管障碍仍然存在,但最近的进展表明,在开发有效的食用和皮内疫苗系统方面取得了进展.
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