人工智能建模用于评估瘤病患者心血管疾病的风险
Samer S Al-Droubi1,2, Eiman Jahangir1, Karl M Kochendorfer3
1Vanderbilt University Medical Center, 1211 Medical Center Dr, Nashville, TN 37232, USA.
European heart journal. Digital health
|August 4, 2023
概括
机器学习模型可以准确地识别患有心血管疾病风险的癌症患者,改善对心脏瘤学的转诊. 这些工具通过预测心脏毒性风险来增强患者护理.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 机器学习 机器学习
背景情况:
- 对于瘤学家来说,缺乏全面的机器学习 (ML) 工具来识别患有心血管疾病风险的癌症患者.
- 及时转诊到心脏瘤医院对于管理与治疗有关的心脏毒性至关重要.
研究的目的:
- 应用ML算法来识别患有心血管疾病风险的瘤患者.
- 为了生成护理质量的风险评分,并支持对心脏瘤的转诊.
主要方法:
- 利用了来自范德比尔特大学医学中心的非身份患者数据.
- 应用随机森林 (RF) 和人工神经网络 (ANN) ML模型用于包括乳腺癌,癌,B细胞淋巴瘤和免疫治疗患者在内的队列.
- 分析了20023份患者记录,数据随机分为80%的培训和20%的测试集.
主要成果:
- 两种RF和ANN模型都实现了90%以上的准确性和曲线下的面积 (AUC).
- ANN模型的性能优于RF模型,在识别有风险的患者方面表现出更高的准确性.
- 有限的验证表明,86%的淋巴瘤和58%的患有严重心脏毒性风险的癌患者最初没有被转诊到心脏瘤学.
结论:
- 开发的预测性ML模型已经准备好整合到瘤实践中.
- 模型将集成到电子健康记录中,以标记需要心脏瘤转诊的患者.
- 这些模型的运行支持心脏瘤实践,旨在改善患者监测和针对心脏毒性的量身定制治疗.
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