关于基于致病的治疗方案的建议,以减少氧酸盐结石复发的可能性
Saeed R Khan1, Benjamin K Canales2
1Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA.
Asian journal of urology
|August 4, 2023
概括
石复发是很常见的. 实验研究表明,抗氧化剂和RAAS抑制剂可以通过向氧化应激和炎症来帮助预防结石,从而补充标准疗法.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生物化学 生化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 全球结石疾病的患病率正在上升,复发率高 (30-50%).
- 目前的治疗重点是减少尿道矿物质过和,但还有其他结石形成的途径.
- 异常性酸盐石块涉及兰达尔斑块,氧化应激和特定的分子通路参与了它们的形成.
研究的目的:
- 审查关于用于预防石复发的易用化合物的实验研究.
- 探索超和减少之外的新型治疗点.
主要方法:
- 进行了相关研究的文献综述,截至2020年10月.
- PubMed被用作文学搜索的主要数据库.
主要成果:
- 实验研究表明,反应性氧物种,氧化应激,氨酸-氨酸-阿尔多斯特系统 (RAAS),尼古丁胺氨酸二核酸盐 (NADPH) 氧化酶和NLRP3炎症酶在石头病原发生过程中参与其中.
- 像他类药物和 ангиотензин转化酶抑制剂这样的化合物在动物模型中显示出降低氧沙酸腎病的潜力.
结论:
- 除了标准疗法之外,抗氧化剂,自由基清除剂和NADPH氧化酶,NLRP3炎症酶和RAAS的抑制剂可能为石头预防提供好处.
- 虽然人类临床证据有限,但实验数据支持将这些药物与患者咨询的常规治疗一起考虑.
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