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人工卵细胞激活在改善贫困应答者的生殖结果中的有效性:单中心队列研究

Balpreet Kaur¹, Sonia Malik², Ved Prakash²

¹Department of Obstetrics & Gynaecology, All India Institute of Medical Sciences, Bathinda, Punjab, India.

Journal of family & reproductive health

|August 4, 2023

概括

使用离子体的人工卵细胞激活 (AOA) 在接受细胞内精子注射 (ICSI) 的不良反应者中改善了胚胎发育. 然而,在本研究中,AOA并没有显著提高受精,植入或临床怀孕率.

科学领域:

生殖内分泌学和不孕不育问题
辅助生殖技术 (ART) 是一种辅助生殖技术.
卵细胞生物学和受精过程

背景情况:

卵巢反应不良 (POR) 在通过体外受精 (IVF) 实现怀孕方面是一个重大挑战.
缺陷的卵细胞激活可能导致在细胞内质精子注射 (ICSI) 后的受精失败,即使精液参数正常.
使用离子体进行体外卵细胞激活是改善POR患者受精率的潜在策略.

研究的目的:

通过离子体对卵巢反应不佳的患者进行人工卵细胞激活 (AOA) 的疗效评估.
评估AOA对ICSI后受精,切割,植入和临床怀孕率的影响.

主要方法:

一项前性队列研究,涉及120名卵巢反应不佳的患者 (POSEIDON标准),接受试管婴儿/ICSI.
患者被随机分为两组:ICSI与AOA (使用离子体) 和单独的ICSI (对照).
排除标准:有异常精液参数的伴侣.

主要成果:

与仅使用ICSI的组相比,ICSI与AOA组的受精卵细胞数量,分裂期胚胎数量和A级胚胎数量在统计学上显著增加.
然而,在AOA的受精率,切割率,植入率或临床怀孕率上没有观察到显著的改善.
统计学意义 (p < 0.05) 指出受精卵细胞数量 (2.42 与 2.16 相比),裂解期胚胎 (2.32 与 1.96) 和A级胚胎 (1.52 与 1.04) 的统计意义.

结论:

使用离子体的人工卵细胞激活可增强早期胚胎发育指标,对反应不佳的患者.
AOA在改善整体受精,切割,植入或临床怀孕率方面没有显著的益处.
需要对更大的样本进行进一步的研究,以获得关于AOA在响应较差者中的有效性的确证据.

关键词:

博洛尼亚分类是什么意思离子体是一种离子体.细胞体内精子注射 (ICSI) 的方法波西顿的标准是什么?

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