与代谢功能障碍相关的脂肪肝疾病和肝细胞癌的风险
Byeong Geun Song1, Sung Chul Choi2, Myung Ji Goh1
1Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
JHEP reports : innovation in hepatology
|August 4, 2023
概括
与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 与没有其他肝病的成年人中肝细胞癌 (HCC) 风险较高有关. 新的MAFLD术语在很大程度上与非酒精性脂肪性肝病 (NAFLD) 在这个群体中重叠.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 在瘤学瘤学.
- 代谢疾病 代谢疾病
背景情况:
- 代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是非酒精性脂肪肝疾病 (NAFLD) 的替代方案.
- MAFLD,NAFLD和肝细胞癌 (HCC) 风险之间的关联需要进一步调查.
研究的目的:
- 分析肝细胞癌 (HCC) 风险是否在代谢功能障碍相关的脂肪肝疾病 (MAFLD) 和非酒精性脂肪肝疾病 (NAFLD) 状态之间有所不同.
- 评估MAFLD与NAFLD在无症状成年人中HCC发展的预测价值.
主要方法:
- 对73,691名成年人的大量队列进行了对HCC发展的跟踪.
- 在没有其他肝脏疾病的参与者中诊断出NAFLD (n=65,992).
- 评估了MAFLD和NAFLD状态,并与HCC发病率相关联.
主要成果:
- 患有MAFLD的参与者与没有MAFLD的参与者相比,HCC的发病率更高 (0.37对0.24每1000人年;p=0.006).
- 在多变量分析中,MAFLD不是一个独立的HCC预测因子 (HR 1.21).
- 在没有其他肝病的个体中,MAFLD (aHR 1.84) 和NAFLD (aHR 1.71) 都是独立的HCC预测因子,在这个子组中很大程度上重叠.
结论:
- 在患有其他慢性肝病的患者中,MAFLD与增加的HCC风险没有独立关联.
- 对于没有其他慢性肝病的人来说,MAFLD与NAFLD明显重叠,并且与HCC风险增加有关.
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