消化管静脉瘤预测了补偿高级非酒精性脂肪肝疾病的并发症
Grazia Pennisi1, Marco Enea1, Mauro Viganò2
1Sezione di Gastroenterologia e Epatologia, PROMISE, Università di Palermo, Palermo, Italy.
JHEP reports : innovation in hepatology
|August 4, 2023
概括
食道静脉 (OV) 的存在,大小和进展显著增加了非酒精性脂肪肝疾病相关的补偿性晚期慢性肝病 (NAFLD-cACLD) 患者的脱补偿和门静脉血栓的风险. 监测OV对于风险分层至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 内部医学 内部医学
背景情况:
- 由非酒精性脂肪性肝病 (NAFLD) 来补偿的晚期慢性肝病 (cACLC) 携带并发症的风险.
- 胃肠静脉 (OV) 是一种常见的并发症,但它们对cACLD进展的影响和演变需要进一步评估.
研究的目的:
- 评估食道变节的存在,严重程度和变化如何影响NAFLD相关的cACLD并发症风险.
- 评估非侵入性得分,以预测并发症,并识别低风险患者进行OV查.
主要方法:
- 对629名患有NAFLD相关的cACLD的患者的回顾性分析.
- 包括基线和随访食道胃管腺镜和临床数据.
- 记录去补偿,门静脉血栓塞 (PVT) 和肝细胞癌.
主要成果:
- 小型和大型OV分别存在于30%和15.9%的患者中. OV进展发生在16.3% (新发病) 和22.4% (小到大) 的病例中.
- 糖尿病和BMI增加与OV进展有关.
- 小型和大型OV,以及它们的进展,独立地与减少补偿和PVT的风险增加有关.
结论:
- 在NAFLD相关的cACLD中,OV的存在,严重程度和演变是分层分解和PVT风险的关键因素.
- 非侵入性标记可以帮助预测风险并识别可能不需要立即内镜检查的患者.
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