作为急性胰腺炎患者严重程度和死亡率的预测标记的C-反应蛋白/白蛋白和费里丁
Manas Kumar Behera1, Debakanta Mishra2, Manoj Kumar Sahu2
1Department of Hepatology, SCB Medical College and Hospital, Cuttack, Odisha, India.
Przeglad gastroenterologiczny
|August 4, 2023
概括
C反应蛋白 (CRP) /白蛋白比率是一种简单,廉价的生物标志物,可以准确预测严重急性胰腺炎和死亡率. 费里丁还显示出预测急性胰腺炎中缩的前景.
科学领域:
- 胃肠病学 胃肠病学
- 生物标志物 生物标志物
- 临床预后 临床预后
背景情况:
- 急性胰腺炎 (AP) 是一种严重的胃肠道疾病,死亡率高.
- 目前AP的预后评分系统复杂,昂贵,并不总是准确的.
研究的目的:
- 评估C-反应蛋白 (CRP) /白蛋白比率和ferritin对AP结果的预测准确度.
- 为了确定AP严重性和死亡率的简单,具有成本效益的生物标志物.
主要方法:
- 对116名AP患者进行了前性研究.
- 计算的CT严重性指数 (CTSI),APACHE II分数,血清费里丁和CRP/白蛋白比率.
- 利用考克斯回归多变量分析来确定死亡率的独立预测因素.
主要成果:
- 在严重的AP病例中,CRP/白蛋白比率显著更高 (p < 0.001).
- CRP/白蛋白比率独立预测死亡率 (AOR = 1.26) 并具有预测AP严重性的最高AUC.
- 血清费里丁显示高AUC预测死 (0.89),但不是死亡率的独立预测指标.
结论:
- CRP/白蛋白比率是一种简单,实惠,易于使用的生物标志物,用于预测严重的AP.
- 这一比率是急性胰腺炎患者死亡率的独立预测指标.
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