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相关概念视频

Epigenetic Regulation01:37

Epigenetic Regulation

3.1K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.1K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

34.7K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
34.7K
General Transcription Factors01:30

General Transcription Factors

5.4K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
5.4K
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

6.3K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
6.3K
Transcription Factors02:16

Transcription Factors

76.1K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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相关实验视频

Updated: Jul 20, 2025

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution
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Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution

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组织特定的DNA甲基化变异性及其潜在的临床价值.

Ryan H Miller1, Chad A Pollard2, Kristin R Brogaard1

  • 1Inherent Biosciences, Salt Lake City, UT, United States.

Frontiers in genetics
|August 4, 2023
PubMed
概括

这项研究引入了一种新的诊断工具,用于分析复杂疾病的表观遗传变异性. 它识别了疾病组织中的改变表观遗传模式,并且在预测男性不孕症结果方面表现有前途,特别是在子宫内授精 (IUI) 中.

关键词:
通过DNA甲基化.基因促进剂失调调节的发生.基因促进物甲基化.男人不孕不育的原因精子 DNA DNA 精子 DNA

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Methyl-binding DNA capture Sequencing for Patient Tissues
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Methyl-binding DNA capture Sequencing for Patient Tissues

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Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

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相关实验视频

Last Updated: Jul 20, 2025

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution
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Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution

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Methyl-binding DNA capture Sequencing for Patient Tissues
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科学领域:

  • 表观遗传学和基因组学
  • 复杂疾病的生物标志物
  • 系统生物学方法 系统生物学方法

背景情况:

  • 复杂的疾病由于多因素病因而存在诊断挑战.
  • 目前的诊断生物标志物通常集中在有限的遗传或表观遗传标上.
  • 对于复杂的疾病,需要一种系统层面的方法来分析生物途径.

研究的目的:

  • 开发一种用于分析复杂疾病综合表观遗传特征的诊断工具.
  • 测量基因促进体内的个体内甲基化变异性,以检测全球监管转变.
  • 评估表观遗传变异的组织特异性,与疾病相关的变化和临床效用.

主要方法:

  • 利用来自20种细胞类型和各种疾病的2400多个样本的公开可用的DNA甲基化数据.
  • 开发了一种工具来测量基因促进体的个体内甲基化变异性,而不仅仅是差异甲基化区域.
  • 使用无监督聚类来分析表观遗传变异性模式.

主要成果:

  • 促进体区域的全球表观遗传变异性是组织特异性的.
  • 与正常组织相比,患病的组织表现出改变的表观遗传变异性.
  • 在多种复杂疾病中,表观遗传变异性分析成功地区分了患病和正常组织.

结论:

  • 基因促进者的表观遗传变异性作为细胞调节状态的敏感指标.
  • 开发的工具在评估诸如男性不孕症等多因素状况方面显示出临床实用性.
  • 精子表观遗传变异性与子宫内授精 (IUI) 的活产成功相关,提供了潜在的生殖洞察力.